The Marion Gluck Clinic

A comprehensive review of the safety and efficacy of bioidentical hormones for the management of menopause and related health risks. Bioidentical hormones review.

The purpose of this article was to comprehensively review and evaluate the safety and efficacy of bio-identical hormones in the management of menopausal symptoms. Some of the studies reviewed involved both bio-identical estrogens and progesterone and they were found to be effective in tackling menopausal symptoms and were associated with a reduced risk of blood clots compared to synthetic hormone therapy. One study involving 3,175 post-menopausal women predominantly using natural hormone therapy found there was no increased risk of breast cancer compared with conventional HRT. A second cohort study with 54,548 post-menopausal women found the risk of breast cancer to be significantly greater with HRT involving synthetic hormones versus HRT with bio-identical hormones. These large cohort studies assessing the safety of bio-identical hormones provide significant evidence to support the safety of bio-identical HRT with respect to breast tissue.

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