This study aimed to determine the effect of DHEA replacement therapy over a period of 12 months in a group of 14 post-menopausal women between the age of 60-70. The women received daily application of 10% DHEA cream. The study found that there was vaginal epithelium maturation in 8 out of 10 women who had a maturation value of zero at the onset of replacement therapy. Furthermore, the estrogenic effect of DHEA observed in the vagina was not observed in the endometrium which remained atrophic in all women. Another finding of the study was that the bone mineral density (BMD) significantly increased at the hip after the 12-month treatment period, thus emphasising the benefits of DHEA replacement therapy.
