The Marion Gluck Clinic

Estrogens-Safety and efficacy of oestriol for symptoms of natural or surgically induced menopause.

From the findings of this study, estriol appeared to be safe and effective for relieving post-menopausal symptoms. The study looked at two groups of women; those who had gone through natural menopause (group 1), and those who had gone through surgically induced menopause as a result of a hysterectomy with bilateral oophorectomy (group 2). All women in the study received a daily dose of 2mg estriol for 12 months. The study showed that this daily dose significantly relieved climacteric symptoms, such as hot flushes, sweating, insomnia and dyspareunia, in both groups of post-menopausal women within one month of starting treatment and over the remaining 9 months of the study. The level of satisfaction with the hormone therapy was also measured throughout this study with both groups of women expressing increased satisfaction as the study time increased. Histological evaluation of the endometrium (group 1), and ultrasound assessment of the breasts (both groups) after 12 months showed normal results for all women indicating that estriol appeared to be safe and effective.

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