The aim of this study was to assess the effects of hormone replacement therapy on the risk of cardiovascular and all-cause mortality in women aged between 40 -74 who were receiving treatment with statins. A total of 40,958 statin users (2,862 hormone therapy users and 38,096 non-users) were followed for a mean of 4 years. Overall, the study found that among hormone therapy users, there were 5 cardiovascular deaths per 10,000 person-years; the corresponding rate for non-users was 18. The all-cause mortality rates were 33 (HT-users) and 87 (non-users). The authors concluded that hormone therapy is associated with a reduce risk of all-cause mortality in women who are receiving statins.
