The Marion Gluck Clinic

Natural progesterone and antihypertensive action.

Natural oral progesterone was found to have an antihypertensive effect compared to a placebo in a trial of men and post-menopausal women with mild to moderate hypertension, who were not receiving any treatment for their blood pressure. The results of the study indicate that progesterone causes a significant reduction in blood pressure when administered at a dose that produces a blood plasma concentration just higher than the level measured during the luteal phase. Natural progesterone may be recognised as a “protective” female hormone as following the menopause, blood concentration of progesterone decreases, and this may be associated with the increased incidence of cardiovascular disease and high blood pressure in post-menopausal women. This association may also explain why the statistics for post-menopausal women catch up with men who similarly have a naturally low blood concentration of progesterone.

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