This study aimed to evaluate the safety of DHEA for post-menopausal women. The women in the study were randomised to receive a daily dose of 50mg oral DHEA or a placebo. Over 52 weeks, the effects of DHEA versus the placebo on lipid profile, insulin-glucose homeostasis and the endometrium were studied. Overall, the study found that the administration of 50mg DHEA daily did not significantly affect the lipid profile, insulin sensitivity or the endometrium.